It’s a major bummer that there’s no such thing as a virtualized “.NET Application Container” for the new scalable grid computing and provisioning services coming out (Amazon EC2, MediaTemple’s Grid-Server). Essentially .NET programmers can’t easily take advantage of new long tail models with easily-sourced infrastructure services. Going out on a limb, I’d suggest these limitations contribute to a lot of top/entrepreneurial developer talent moving over to various flavors of the LAMP stack, Ruby, etc.
I think this is yet another area where Microsoft is missing the ball. And it is related to the fact that people can’t build and distribute Windows-based stacks as appliances (i.e. because of licensing issues) in the same way people can build and distribute them for Linux. Mark my words, these two aspects are a significant achillie’s heel for Microsoft and will have significant import in the further decline of the Windows Server and .NET platform.